Illuma

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Human Affinity® Story

 

What is "Bioactive"?

In medical dictionaries, a bioactive substance is defined as a substance having an effect on, causes a reaction, or triggers a response in the living tissue1

There are different bioactive ingredients in lactating secretion, including human milk oligosaccharides (HMO) and immunoglobulin2.

HMO

HMO is third key nutrients in lactating secretion

HMO is third key nutrients in lactating secretion. 2'-FL is the most abundant one while LNnT is one the 10 most abundant HMOs3.

 
 

MOS

MOS contains innate levels of sialyllactose

MOS contains innate levels of sialyllactose. Human milk also contains sialyllactose.

 

Bioactive Affinity Ingredients – 2 types of HMO & MOS*
Clinically proven to support immunity in 3 ways

BLOCK GUT BARRIER

A healthy gut barrier helps to block pathogens from entering the body4.

Unhealthy gut barrier
Healthy gut barrier
Pathogens
MOS contributes to a healthy gut barrier5.

MODULATE GUT MICROBIOTA

Increasing beneficial bacteria in the gut microbiota supports gut health6.

Group that doesn’t consume formula containing 2 types of HMO and MOS
Group that consumes formula containing 2 types of HMO and MOS
Pathogens Beneficial bacteria in the gut
HMO and MOS promote a microbiota similar to breastfed infants7,8.

DEVELOP IMMUNE FUNCTION

The bioactive antibody (sIgA) plays a key role in gastrointestinal immune function9.

Group that doesn’t consume formula containing MOS
Group that consumes formula containing MOS
HMO and MOS help foster immune functions.
In fecal samples, the level of the bioactive antibody, sIgA, was found to be doubled in babies taking products containing MOS2,5.

*2 types of HMO refers to 2’-Fucosyllactose(2’-FL) and Lacto-N-neotetraose (LNnT); MOS refers to Milk oligosaccharides

Revolutionary Bioactive ingredient MOS*

Babies consuming milk formula with MOS7:

2 types of HMO*

Babies consuming formula with 2 types of HMO (2’-FL and LNnT) were found to have a reduced reporting of the below issues10:

*2 types of HMO refers to 2’-Fucosyllactose (2’-FL) and Lacto-N-neotetraose (LNnT); MOS refers to Milk oligosaccharides
^Compared with control group

References:
1. Guaddaoui A et al. Int J Nutr Food Sci. 2014;3(3):174-179.
2. Ballard O, Morrow AL. Pediatr Clin North Am. 2013;60(1):49-74.
3. Urashima T et al. Adv Nutr. 2012;3:473S-482S.
4. Anderson RC et al. Colitis. 2012. DOI: 10.5772/25753.
5. Estorninos E et al. Abstract presented at the FASEB Science Research Conferences Nutritional Immunology and the Microbiota: Rules of Engagement in Health and Disease. 24-29 June 2018, Virginia, USA.
6. O’Neill I et al. Emerg Top Life Sci (2017) 1 (4): 333–349.
7. Estorninos E et al. JPGN. 2019;58(1):999.
8. Steenhout P et al. FASEBJ. 2016;30(Suppl 1):275-277.
9. Bakker-Zierikzee AM et al. Pediatr Allergy Immunol. 2006;17:134-140.
10. Puccios G et al. JPGN. 2017;64(4):624-631.